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Báo cáo y học: "Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis. | Lorente et al. Critical Care 2011 15 R97 http ccforum.eom content 15 2 R97 KS CRITICAL CARE RESEARCH Open Access Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis I ì I z ZZ Fz 1K ỉ V P S R I R I 2 l I z rry s rz 3 11 I IV ỉ rf D z rrz zi I I M Z I Z X A v 4 I z zzd I c z I zA f r I L .5 I r zA D I Z t I I M 6 Leonardo Lorente Maria M Martin Nerea varo Juan Maria Borreguero-Leon Jordi Soié-vioian José Bianquer I riranv i I TỉhTỉri 7 rócnr PiÍ2 78 Ạ loionrlrn Iimónci79 Cz-ji inrrl ì Dtỉcìtm 1 Polito Rolmr mt o2 I CI mo C lrHo10 Lorenzo Labaita Césai Diaz Aiejandio Jimenez Eduaido Pastor Feiipe Deimonie Josune Oibe José A Rodríguez10 Eduardo Gomez-Meiini4 José M Ferrer-Aguero5 José Ferreres6 María C LLiminana11 José A Páramo10 Abstract Introduction CD40 Ligand CD40L and its soiubie counterpart sCD40L are proteins that exhibit prothrombotic and proinfiammatory properties on binding to their ceii surface receptor CD40. The resuits of smaii ciinicai studies suggest that sCD40L ieveis couid piay a roie in sepsis however there are no data on the association between sCD40L ieveis and mortaiity of septic patients. Thus the aim of this study was to determine whether circuiating sCD40L ieveis couid be a marker of adverse outcome in a iarge cohort of patients with severe sepsis. Methods This was a muiticenter observationai and prospective study carried out in six Spanish intensive care units. Serum ieveis of sCD40L tumour necrosis factor-aipha and interieukin-10 and piasma ieveis of tissue factor were measured in 186 patients with severe sepsis at the time of diagnosis. Serum sCD40L was aiso measured in 50 age- and sex-matched controis. Survivai at 30 days was used as the endpoint. Results Circuiating sCD40L ieveis were significantiy higher in septic patients than in controis P 0.01 and in non-survivors n 62 compared to survivors n 124 P 0.04 . However the ieveis of CD40L were not different regarding sepsis severity. Logistic .