tailieunhanh - Báo cáo y học: "Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men. | Int. J. Med. Sci. 2007 4 216 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2007 4 4 216-222 Ivyspring International Publisher. All rights reserved Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men Mariko Naito 1 Koichi Miyaki 2 Toru Naito 3 Ling Zhang 4 Keika Hoshi 5 Asako Hara 6 Katsunori Masaki 6 Shugo Tohyama 6 Masaaki Muramatsu4 Nobuyuki Hamajima 1 Takeo Nakayama 2 1. Department of Preventive Medicine Biostatistics and Medical Decision Making Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan 2. Department of Health Informatics Kyoto University School of Public Health Yoshida konoe-cho Sakyo-ku Kyoto 606-8501 Japan 3. Department of General Dentistry Fukuoka Dental College 2-15-1 Tamura Sawara-ku Fukuoka 814-0193 Japan 4. Department of Molecular Epidemiology Medical Research Institute Tokyo Medical and Dental University 2-3-10 Kandasurugadai Chiyoda-ku Tokyo 101-0062 Japan 5. Information Design Section Center for Information Research and Library National Institute of Public Health 2-3-6 Minami Wako Saitama 351-0197 Japan 6. Keio University Hospital 35 Shinanomachi Shinjuku-ku Tokyo 160-8582 Japan Correspondence to Mariko Naito Tel 81-52-744-2132 Fax 81-52-744-2971 E-mail mnaito@ Received Accepted Published Background The vitamin D receptor VDR is involved in a variety of biological processes such as bone metabolism and modulation of the immune response. Recent findings suggest that the pathway involving bone mineral density-mediated effects is important for the development of periodontitis but their effects of combined VDR gene polymorphisms have not been confirmed on periodontitis. We assessed the relationship between ApaI BsmI and Fokl VDR polymorphisms and the risk of severe chronic periodontitis among Japanese adult men. Materials and Methods In a cross-sectional study we .

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