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Báo cáo y học: ":RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes. | Open Access Software RASTA-Bacteria a web-based tool for identifying toxin-antitoxin loci in prokaryotes Emeric W Sevin and Frédérique Barloy-Hubler ỷ Addresses CNRS UMR6061 Génétique et Développement Université de Rennes 1 IFR 140 Av. du Prof. Léon Bernard CS 34317 35043 Rennes France. CNRS UMR6026 Interactions Cellulaires et Moléculaires Groupe DUALS Université de Rennes 1 IFR140 Campus de Beaulieu Av. du Général Leclerc 35042 Rennes France. Correspondence Frédérique Barloy-Hubler. Email fhubler@univ-rennes1.fr Published I August 2007 Genome Biology 2007 8 RI55 doi I0.II86 gb-2007-8-8-rI 55 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 8 RI55 Received 29 March 2007 Revised I4 June 2007 Accepted I August 2007 2007 Sevin and Barloy-Hubler licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Toxin antitoxin TA systems viewed as essential regulators of growth arrest and programmed cell death are widespread among prokaryotes but remain sparsely annotated. We present RASTA-Bacteria an automated method allowing quick and reliable identification of TA loci in sequenced prokaryotic genomes whether they are annotated open reading frames or not. The tool successfully confirmed all reported TA systems and spotted new putative loci upon screening of sequenced genomes. RASTA-Bacteria is publicly available at http genoweb.univ-rennesI.fr duals RASTA-Bacteria. Rationale More than 500 prokaryotic genomes have now been completely sequenced and annotated and the number of sequencing projects underway approximately 1 300 indicates that the amount of such data is going to rise very rapidly 1 2 . Large-scale comparative genomics based on these data constituted a giant .