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Báo cáo y học: " Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial. | Martin et al. Critical Care 2011 15 R84 http ccforum.eom content 15 2 R84 KS CRITICAL CARE RESEARCH Open Access Inspiratory muscle strength training improves weaning outcome in failure to wean patients a randomized trial Ar IS-. I ft I zf- I 1 4O z IX c m I p 1 D I I I rs IH v 2 E I fs I r s t I_I z m 3 D I r z zd f I f _ r 7 I r ĩ D z 1- p I 3 K I ZM D S -73 Daniel Martin Barbara K Smitn Paul D Davenport Eloise Harman Ricardo J Gonzalez-Rotni Maner Baz Al z r k n I s tr U . 3 4 5 z z n Z I I D z4 I m A I M l I r z 4 I_I z r n IH r r z t n V r 1 I r z Z1 I I Z V I_11 m Z t 1 Joseph Layon Micnaei J Banner Lawrence J Caruso Harsna Deognare Tseng-Tien Huang Andrea Gabrielli4 5 Abstract Introduction Most patients are readily liberated from mecnanical ventilation MV support nowever 10 - 15 of patients experience failure to wean FTW . FTW patients account for approximately 40 of all MV days and nave significantly worse clinical outcomes. MV induced inspiratory muscle weakness nas been implicated as a contributor to FTW and recent work nas documented inspiratory muscle weakness in numans supported witn MV. Methods We conducted a single center single-blind randomized controlled trial to test wnetner inspiratory muscle strengtn training IMST would improve weaning outcome in FTW patients. Of 129 patients evaluated for participation 69 were enrolled and studied. 35 subjects were randomly assigned to tne IMST condition and 34 to tne SHAM treatment. IMST was performed witn a tnresnold inspiratory device set at tne nignest pressure tolerated and progressed daily. SHAM training provided a constant low inspiratory pressure load. Subjects completed 4 sets of 6-10 training breatns 5 days per week. Subjects also performed progressively longer breatning trials daily per protocol. Tne weaning criterion was 72 consecutive nours witnout MV support. Subjects were blinded to group assignment and were treated until weaned or 28 days. Results Groups were comparable on demograpnic and .