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Báo cáo y học: "Celsius: a community resource for Affymetrix microarray data"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Celsius: a community resource for Affymetrix microarray data. | Open Access Method Celsius a community resource for Affymetrix microarray data Allen Day Marc RJ Carlson Jun Dong Brian D O Connor and Stanley F Nelson Address Department of Human Genetics David Geffen School of Medicine University of California Los Angeles California 90095 USA. Correspondence Stanley F Nelson. Email snelson@ucla.edu Published 14 June 2007 Genome Biology 2007 8 R112 doi l0.ll86 gb-2007-8-6-rl 12 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 6 R112 Received 2 February 2007 Revised 9 May 2007 Accepted l4 June 2007 2007 Day et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Celsius is a data warehousing system to aggregate Affymetrix CEL files and associated metadata. It provides mechanisms for importing storing querying and exporting large volumes of primary and pre-processed microarray data. Celsius contains ten billion assay measurements and affiliated metadata. It is the largest publicly available source of Affymetrix microarray data and through sheer volume it allows a sophisticated broad view of transcription that has not previously been possible. Background DNA microarrays have become the most important source of experimental genomic information that are applied in a large scale. They are widely used for tissue disease classification as well as gene function discovery. Applications of this technology are routinely and widely published within almost all aspects of biology and human disease studies with more than 14 000 PubMed citations containing the word microarray published between 1996 and 2007. Even in the early years of microarray experimentation it was widely recognized that a central repository of this information .