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Báo cáo y học: " Coinfection with EBV/CMV and other respiratory agents in children with suspected infectious mononucleosis"
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Coinfection with EBV/CMV and other respiratory agents in children with suspected infectious mononucleosis | Wang et al. Virology Journal 2010 7 247 http www.virologyj.eom content 7 1 247 VIROLOGY JOURNAL RESEARCH Open Access Coinfection with EBV CMV and other respiratory agents in children with suspected infectious mononucleosis Xia Wang1 2 Kun Yang1 Cong Wei1 Yuan Huang1 Dongchi Zhao1 Abstract Background Numerous studies have shown that Epstein-Barr virus EBV and cytomegalovirus CMV can infect immunocompetent patients simultaneously with other agents. Nonetheless multiple infections with other agents in EBV CMV-infected children have received little attention. We conducted a retrospective study of children with suspected infectious mononucleosis. Peripheral blood samples were analyzed by indirect immunofluorescence to detect EBV CMV and other respiratory agents including respiratory syncytial virus adenovirus influenza virus types A and B parainfluenza virus types 1 2 and 3 Chlamydia pneumoniae and Mycoplasma pneumoniae. A medical history was collected for each child. Results The occurrence of multipathogen infections was 68.9 81.3 and 63.6 in the children with primary EBV CMV or EBV CMV respectively which was significantly higher than that in the past-infected group or the uninfected group p 0.001 . Of the multipathogen-infected patients the incidence of C. pneumoniae in children with primary infection was as high as 50 significantly higher than in the other groups p 0.001 . In the patients with multipathogen infection and EBV CMV primary infection fever rash lymphadenopathy hepatomegaly splenomegaly atypical lymphocytes and abnormal liver function were more frequent and the length of hospital stay and duration of fever were longer than in other patients. Conclusion Our study suggests that there is a high incidence of multipathogen infections in children admitted with EBV CMV primary infection and that the distribution of these pathogens is not random. Introduction Epstein-Barr virus EBV and Cytomegalovirus CMV members of the herpesvirus family are common viruses that