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Báo cáo y học: " Low hemoglobin is associated with poor functional outcome after non-traumatic, supratentorial intracerebral hemorrhag"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Low hemoglobin is associated with poor functional outcome after non-traumatic, supratentorial intracerebral hemorrhage. | Diedler et al. Critical Care 2010 14 R63 http ccforum.eom content 14 2 R63 c CRITICAL CARE RESEARCH Open Access Lowbemoglobin is associated with poor functional outcome after non-traumatic supratentorial intracerebral hemorrhage Jennifer Diedler 21 MarekSykora 1 2 Philipp Hahn 1 Kristin Heerlein1 Marion N Scholzke1 Lars Kellert1 Julian Bosel1 Sven Poli1 and Thorsten Steiner1 Abstract Introduction The impact of anemia on functional outcome and mortality in patients suffering from non-traumatic intracerebral hemorrhage ICH has not been investigated. Here we assessed the relationship between hemoglobin HB levels and clinical outcome after ICH. Methods One hundred and ninety six patients suffering from supratentorial non-traumatic ICH were extracted from our local stroke database June 2004 to June 2006 . Clinical and radiologic computed tomography data HB levels on admission mean HB values and nadir during hospital stay were recorded. Outcome was assessed at discharge and 3 months using the modified Rankin score mRS . Results Forty six 23.5 patients achieved a favorable functional outcome mRS 3 and 150 76.5 had poor outcome mRS 4 - 6 at discharge. Patients with poor functional outcome had a lower mean HB 12.3 versus 13.7 g dl P 0.001 and nadir HB 11.5 versus 13.0 g dl P 0.001 . Ten patients 5.1 received red blood cell RBC transfusions. In a multivariate logistic regression model the mean HB was an independent predictor for poor functional outcome at three months odds ratio OR 0.73 95 confidence interval CI 0.58-0.92 P 0.007 along with National Institute of Health Stroke Scale NIHSS at admission OR 1.17 95 CI 1.11 - 1.24 P 0.001 and age OR 1.08 95 CI 1.04 - 1.12 P 0.001 . Conclusions We report an association between low HB and poor outcome in patients with non-traumatic supratentorial ICH. While a causal relationship could not be proven previous experimental studies and studies in brain injured patients provide evidence for detrimental effects of anemia on brain .