Đang chuẩn bị liên kết để tải về tài liệu:
Particle Toxicology - Chapter 21

Những năm gần đây đã chứng kiến sự tăng trưởng chưa từng có nghiên cứu và ứng dụng trong lĩnh vực khoa học nano và công nghệ nano. Có gia tăng sự lạc quan rằng công nghệ nano, áp dụng cho y học, sẽ mang lại những tiến bộ quan trọng trong chẩn đoán và điều trị bệnh. | 21 Nanoparticles in Medicine Paul J. A. Borm Centre of Expertise in Life Sciences Hogeschool Zuyd Detlef Muller-Schulte Magnamedics GmbH CONTENTS 21.1 Introduction.387 21.2 Particles in Nanomedicine Health Benefits and Perspectives.388 21.2.1 Imaging and Diagnostic Tools.388 21.2.1.1 Magnetic Particles.388 21.2.1.2 Fluorescent Nanoparticles.390 21.2.1.3 Quantum Dots.391 21.2.2 Nanomaterials and Nanodevices .392 21.2.3 Drug Delivery Tools.393 21.2.3.1 Liposomes.394 21.2.3.2 Magnetoliposomes.395 21.2.3.3 Dendrimers .397 21.2.3.4 Fullerenes .398 21.2.3.5 Polymer Carriers.398 21.2.3.6 Magnetic Nanocarriers.399 21.3 Hazards and Risks of Nanoparticles.401 21.3.1 General Concepts.401 21.3.2 Toxicological Effects of Nanoparticles.402 21.3.2.1 Effects on Blood and Cardiovascular System.402 21.3.2.2 Uptake and Effects of Nanoparticles in the Brain.402 21.3.3 Current Data on the Toxicology of Engineered Nanoparticles.403 21.3.3.1 Quantum Dots.403 21.3.3.2 Carbon Nanotubes.403 21.3.3.3 Fullerenes.404 21.3.3.4 Dendrimers .404 21.3.3.5 Wear Particles from Implants.404 21.3.4 Nanomaterials in Medicine Future Toxicological Needs.405 References.406 21.1 INTRODUCTION Recent years have witnessed unprecedented growth of research and applications in the area of nanoscience and nanotechnology. There is increasing optimism that nanotechnology as applied to medicine will bring significant advances in the diagnosis and treatment of disease. Anticipated 387 2007 by Taylor Francis Group LLC 388 Particle Toxicology applications in medicine include drug delivery diagnostics nutraceuticals and production of biocompatible materials ESF 2005 Ferrari 2005 Vision Paper 2005 . Engineered nanoparticles 100nm or nanostructured materials NSM are important tools to realize these applications. The reason why these nanoparticles NP are attractive for such purposes is based on their important and unique features such as their surface to mass ratio that is much larger than that of other particles their .