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Báo cáo y học: " Reporting clinical trials of psychosocial interventions in child and adolescent psychiatry and mental health"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Reporting clinical trials of psychosocial interventions in child and adolescent psychiatry and mental health. | Goldbeck and Vitiello Child and Adolescent Psychiatry and Mental Health 2011 5 4 http www.capmh.eom content 5 1 4 CHILD ADOLESCENT PSYCHIATRY MENTAL HEALTH EDITORIAL Open Access Reporting clinical trials of psychosocial interventions in child and adolescent psychiatry and mental health Lutz Goldbeck1 Benedetto Vitiello2 Editorial Randomized Clinical Trials RCTs are a powerful although not the only way of scientifically investigating treatment efficacy and effectiveness. As early as 1753 the Scottish physician James Lind used this method to test the effect of citric acid in the prevention of scurvy when he randomly assigned sailors to six treatment arms. By the middle of the 20th century RCTs had become the gold standard of evidence based medicine. The first published RTC demonstrated the efficacy of streptomycin in tuberculosis even though under double-blind conditions or with a placebo control condition 1 . Compared with pharmacology research the application of the RCT to psychotherapy research has taken time to be widely adopted. In 1990 concordant with the emerging paradigm of Evidence Based Medicine EBM the American Psychological Association developed criteria for considering psychological treatments as evidence-based and recommended either RCT group designs or a large series of single case experiments together with the development of treatment manuals a clear specification of trial participants and the need to replicate a finding of efficacy 2 . A number of criticisms of this position have been put forward based on issues such as the difficulty of designing a placebo-like control the impossibility of maintaining double-blind conditions the challenge of standardizing interventions the importance of the therapist-patient fit and the reduced external validity of psychotherapy in the context of a RCT 3 . In spite of these limitations since no valid alternatives currently exist for producing generalizable evidence the RCT is now accepted as the best way of proving