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Báo cáo y học: "Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysi"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis. | Available online http ccforum.eom content 13 4 R119 Research Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis a prospective observational analysis Holger Poehlmann1 A Joerg C Schefold1 2 Heidrun Zuckermann-Becker3 Hans-Dieter Volk1 4 and Christian Meisel1 Open Access Department of Medical Immunology Charité Universitatsmedizin Berlin Campus Mitte Chariteplatz 1 Berlin 10117 Germany 2Department of Nephrology and Intensive Care Medicine Charité Universitatsmedizin Berlin Campus Vichow Clinic Augustenburger Platz 1 Berlin 13353 Germany department of General Surgery Charité Universitatsmedizin Berlin Campus Mitte Chariteplatz 1 Berlin 10117 Germany 4Berlin-Brandenburg Center for Regenerative Therapies Charité Universitatsmedizin Berlin Campus Virchow Clinic Augustenburger Platz 1 Berlin 13353 Germany Corresponding author Christian Meisel chr.meisel@charite.de A Deceased Received 19 Mar 2009 Revisions requested 12 May 2009 Revisions received 10 Jun 2009 Accepted 15 Jul 2009 Published 15 Jul 2009 Critical Care 2009 13 R11 9 doi 10.1186 cc7969 This article is online at http ccforum.com content 13 4 R119 2009 Poehlmann et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Patients with sepsis often demonstrate severely impaired immune responses. The hallmark of this state of immunoparalysis is monocytic deactivation characterized by decreased human leukocyte antigen HLA -DR expression and reduced production of proinflammatory cytokines. Recently diminished numbers of dendritic cells DCs were reported in patients with sepsis. However little is known about DC phenotype and function in human sepsis. We therefore compared phenotypic and functional changes in monocyte and .

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