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Báo cáo y học: "Evaluating movement disorders in pediatric patients receiving risperidone: a comparison of spontaneous reports and research criteria for TD"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Evaluating movement disorders in pediatric patients receiving risperidone: a comparison of spontaneous reports and research criteria for TD. | Child and Adolescent Psychiatry and Mental Health BioMed Central Open Access Evaluating movement disorders in pediatric patients receiving risperidone a comparison of spontaneous reports and research criteria for TD Gahan J Pandina 1 Cynthia A Bossie1 Young Zhu1 and Georges M Gharabawi2 3 Address 1Ortho-McNeil Janssen Scientific Affairs L.L.C. Titusville NJ USA 2Ortho-McNeil Janssen Scientific Affairs L.L.C. Titusville NJ USA and 3Current address Roche Pharmaceuticals Nutley NJ USA Email Gahan J Pandina - gpandina@prdus.jnj.com Cynthia A Bossie - cbossie@janus.jnj.com Young Zhu - yzhu6@omjus.jnj.com Georges M Gharabawi - george.garibaldi@roche.com Corresponding author Published 26 June 2007 Received 28 February 2007 Child and Adolescent Psychiatry and Mental Health 2007 1 3 doi 10.1186 1753-2000-1-3 Accepted 26 June 2007 This article is available from http www.capmh.cOm content 1 1 3 2007 Pandina et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Movement disorders MD in children are relatively common and may be associated with medication use. Objective methods ie rating scales and specific research criteria may be helpful in identifying MD-related adverse events that would otherwise not be apparent from spontaneous reports. We assessed whether more stringent and rigorous criteria would provide MD rates similar to those derived subjectively from spontaneous reports. Methods MDs were assessed in children with disruptive behavior disorders DBDs and subaverage intelligence receiving risperidone. Data were from three l-year open-label studies in subjects 4-14 years old. Dyskinesia severity was rated by the Extrapyramidal Symptom Rating Scale ESRS dyskinesia subscale. Tardive dyskinesia TD was defined mild