tailieunhanh - Báo cáo y học: "Evaluating dosage compensation as a cause of duplicate gene retention in Paramecium tetraurelia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Evaluating dosage compensation as a cause of duplicate gene retention in Paramecium tetraurelia. | Minireview Evaluating dosage compensation as a cause of duplicate gene retention in Paramecium tetraurelia Timothy Hughes Diana Ekman Himanshu Ardawatia Arne Elofsson and David A Liberies Addresses Computational Biology Unit Bergen Center for Computational Science University of Bergen 5020 Bergen Norway. Department of Biochemistry and Biophysics Stockholm University 10691 Stockholm Sweden. Department of Molecular Biology University of Wyoming Laramie WY 82071 USA. Correspondence David A Liberles. Email liberles@ Published 22 May 2007 Genome Biology 2007 8 213 doi gb-2007-8-5-2l3 The electronic version of this article is the complete one and can be found online at http 2007 8 5 213 2007 BioMed Central Ltd Abstract The high retention of duplicate genes in the genome of Paramecium tetraurelia has led to the hypothesis that most of the retained genes have persisted because of constraints due to gene dosage. This and other possible mechanisms are discussed in the light of expectations from population genetics and systems biology. Many genomes display extensive gene duplication which may result from either small-scale duplications or from duplication of the whole genome. What determines whether both copies of a duplicate gene are retained in the genome and their subsequent evolutionary fate is still a matter of debate. Aury et al. 1 have recently characterized gene duplication in the ciliate Paramecium tetraurelia a unicellular eukaryote which appears to have undergone multiple rounds of whole-genome duplication with a high level of retention of the duplicate copies. They suggest that this high level of retention is due to constraints arising from gene dosage rather than other proposed mechanisms. Here we discuss these results in relation to the various models proposed for gene duplication and retention. When duplication of a gene or genome occurs in an individual organism it will only become part of the species genome if it becomes .