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Báo cáo y học: " Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components. | Liao et al. Chinese Medicine 2011 6 6 http www.cmjournal.Org content 6 1 6 CHINESE MEDICINE REVIEW Open Access Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa Wuzhuyu and its major bioactive components Jyh-Fei Liao1 Wen-Fei Chiou2 Yuh-Chiang Shen2 Guei-Jane Wang2 Chieh-Fu Chen1 2 Abstract This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases cyclooxygenase NADPH oxidase nuclear factor kappa B hypoxia-inducible factor 1 alpha reactive oxygen species prostaglandins tumor necrosis factor LIGHT amyloid protein and orexigenic neuropeptides. Their potential applications for the treatment of endotoxaemia obesity diabetes Alzheimer s disease and their uses as cardiovascular and gastrointestinal protective agents analgesics anti-oxidant anti-atherosclerosis agents dermatological agents and anti-infectious agents are highlighted. Stimulation of calcitonin gene-related peptide release may partially explain the analgesic cardiovascular and gastrointestinal protective anti-obese activities of Evodia rutaecarpa and its major bioactive components. Introduction Inflammation is a protective physiological response of an organism to chemical physical infectious agents environmental toxins ischemia or an antigen-antibody interaction. However prolonged or overactive inflammation may cause tissue damage. Inflammation is very common manifested as body temperature change edema itch and pain occasionally as serious as septic shock tissue cirrhosis necrosis or cancer. In the United States over 500 000 patients suffer from sepsis triggered by severe systemic inflammation per year 1 . Various factors are involved in inflammation such as calcium homeostasis histamine bradykinin serotonin 5-HT eicosanoids prostaglandins PG thromboxanes TX leukotrienes LT platelet-activating factor hormones corticosterones cytokines interleukins IL chemotaxics .