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báo cáo khoa học: " Abuse risks and routes of administration of different prescription opioid compounds and formulations"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Abuse risks and routes of administration of different prescription opioid compounds and formulations | Butler et al. Harm Reduction Journal 2011 8 29 http www.harmreductionjournal.eom content 8 1 29 HARM REDUCTION JOURNAL RESEARCH Open Access Abuse risks and routes of administration of different prescription opioid compounds and formulations Stephen F Butler Ryan A Black Theresa A Cassidy Taryn M Dailey and Simon H Budman Abstract Background Evaluation of tamper resistant formulations TRFs and classwide Risk Evaluation and Mitigation Strategies REMS for prescription opioid analgesics will require baseline descriptions of abuse patterns of existing opioid analgesics including the relative risk of abuse of existing prescription opioids and characteristic patterns of abuse by alternate routes of administration ROAs . This article presents for one population at high risk for abuse of prescription opioids the unadjusted relative risk of abuse of hydrocodone immediate release IR and extended release ER oxycodone methadone IR and ER morphine hydromorphone IR and ER fentanyl IR and ER oxymorphone. How relative risks change when adjusted for prescription volume of the products was examined along with patterns of abuse via ROAs for the products. Methods Using data on prescription opioid abuse and ROAs used from 2009 Addiction Severity Index-Multimedia Version ASI-MV Connect assessments of 59 792 patients entering treatment for substance use disorders at 464 treatment facilities in 34 states and prescription volume data from SDI Health LLC unadjusted and adjusted risk for abuse were estimated using log-binomial regression models. A random effects binary logistic regression model estimated the predicted probabilities of abusing a product by one of five ROAs intended ROA i.e. swallowing whole snorting injection chewing and other. Results Unadjusted relative risk of abuse for the 11 compound formulations determined hydrocodone and IR oxycodone to be most highly abused while IR oxymorphone and IR fentanyl were least often abused. Adjusting for prescription volume suggested .