tailieunhanh - Báo cáo y học: "The use and abuse of commercial kits used to detect autoantibodies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The use and abuse of commercial kits used to detect autoantibodies. | Arthritis Research Therapy Vol 5 No 4 Fritzler et al. Review The use and abuse of commercial kits used to detect autoantibodies Marvin J Fritzler1 Allan Wiik2 Mark L Fritzler1 and Susan G Barr1 1 Faculty of Medicine University of Calgary Alberta Canada 2Department of Autoimmunology Statens Serum Institut Copenhagen Denmark Correspondence Marvin J Fritzler e-mail fritzler@ Received 1 Apr 2003 Revisions requested 29 Apr 2003 Revisions received 1 May 2003 Accepted 6 May 2003 Published 9 Jun 2003 Arthritis Res Ther 2003 5 192-201 DOI ar782 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract The detection of autoantibodies in human sera is an important approach to the diagnosis and management of patients with autoimmune conditions. To meet market demands manufacturers have developed a wide variety of easy to use and cost-effective diagnostic kits that are designed to detect a variety of human serum autoantibodies. A number of studies over the past two decades have suggested that there are limitations and concerns in the use and clinical application of test results derived from commercial kits. It is important to appreciate that there is a complex chain of users and circumstances that contributes to variations in the apparent reliability of commercial kits. The goal of this review is to identify the principal links in this chain to identify the factors that weaken the chain and to propose a plan of resolution. It is suggested that a higher level of commitment and partnership between all of the participants is required to achieve the goal of improving the quality of patient care through the use of autoantibody testing and analysis. Keywords autoantibodies autoimmunity diagnosis diagnostic kits quality assurance standardization Introduction Over the past five decades the detection of autoantibodies in human sera has become an increasingly important approach to the diagnosis and management of patients with a variety of autoimmune .