tailieunhanh - báo cáo khoa học: " Can abuse deterrent formulations make a difference? Expectation and speculation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Can abuse deterrent formulations make a difference? Expectation and speculation | Harm Reduction Journal BioMed Central Open Access Can abuse deterrent formulations make a difference Expectation and speculation Simon H Budman Jill M Grimes Serrano and Stephen F Butler Address Inflexxion Inc 320 Needham St Suite 100 Newton Massachusetts 02464 USA Email Simon H Budman - simonbudman@ Jill M Grimes Serrano - jgrimesserrano@ Stephen F Butler - sfbutler@ Corresponding author Published 29 May 2009 Received 9 February 2009 Harm Reduction Journal 2009 6 8 doi 1477-7517-6-8 Accepted 29 May 2009 This article is available from http content 6 1 8 2009 Budman et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ It is critical that issues surrounding the abuse and misuse of prescription opioids be balanced with the need for these medications for the treatment of pain. One way to decrease the abuse of prescription opioid medications is to develop abuse deterrent formulations or ADFs that in some way prevent drug abusers from extracting out the active ingredient in order to employ alternate routes of administration such as injection snorting and smoking. Several factors including the pharmacokinetic profile of the drug the features of the drug formulation that make it attractive or unattractive for abuse the type of drug abuser the progression of one s addiction pathway and one s social environment may all play a role in the abuse of prescription opioids and what methods are used to abuse these drugs. This paper will examine these factors in order to understand how they affect the abuse of prescription opioids and routes of administration and how the .