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Báo cáo y học: "Circulating immune complexes and complement C3 and C4 levels in a selected group of patients with rhinitis in Lebanon"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Circulating immune complexes and complement C3 and C4 levels in a selected group of patients with rhinitis in Lebanon. | Clinical and Molecular Allergy BioMed Central Research Open Access Circulating immune complexes and complement C3 and C4 levels in a selected group of patients with rhinitis in Lebanon Alexander M Abdelnoor 1 Firas Kobeissy1 2 Daad Farhat1 and Usamah Hadi3 Address department of Microbiology Immunology Faculty of Medicine American University of Beirut P. O. Box 11-0236 Riad el-Solh Beirut 11072020 Lebanon department of Neuroscience University of Florida Gainsville FL 32608 USA and department of Otolaryngology Faculty of Medicine American University of Beirut P. O. Box 11-0236 Riad el-Solh Beirut 11072020 Lebanon Email Alexander M Abdelnoor - aanoor@aub.edu.lb Firas Kobeissy - firasko@ufl.edu Daad Farhat - df01@aub.edu.lb Usamah Hadi - uhadi@dm.net.lb Corresponding author Published 22 April 2004 Received 30 December 2003 Accepted 22 April 2004 Clinical and Molecular Allergy 2004 2 6 This article is available from http www.clinicalmolecularallergy.cOm content 2 1 6 2004 Abdelnoor et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background A number of reports indicate that circulating immune complexes CIC and activation of the complement system contribute to the pathogenesis of Type I allergy. The aim of this study was to investigate the status of CIC in 113 patients with rhinitis in Lebanon and determine complement components C3 and C4 serum levels in the CIC-positive patients. Serum specific IgE antibodies were previously detected and reported in 74 of the 113 patients. Methods CIC were detected by polyethylene glycol precipitation and serum C3 and C4 levels quantified by radial immunodiffusion. Results CIC was positive in 20 of the specific IgE-positive and 13 of the specific IgE-negative patients. C3 and C4 levels were within the normal range in all the 33 CIC-positive .