tailieunhanh - Báo cáo y học: "Bench-to-bedside review: Circulating microparticles - a new player in sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Circulating microparticles - a new player in sepsis? | Meziani et al. Critical Care 2010 14 236 http content 14 5 236 CRITICAL CARE REVIEW L_ Bench-to-bedside review Circulating microparticles - a new player in sepsis Ferhat Meziani1 2 Xavier Delabranche1 2 3 Pierre Asfar4 5 and Florence loti3 6 7 Abstract In sepsiS inflammation and thrombosis are both the cause and the result of interactions between circulating for example leukocytes and platelets endothelial and smooth muscle cells. Microparticles are proinflammatory and procoagulant fragments originating from plasma membrane generated after cellular activation and released in body fluids. In the vessel they constitute a pool of bioactive effectors pulled from diverse cellular origins and may act as intercellular messengers. Microparticles expose phosphatidylserine a procoagulant phospholipid made accessible after membrane remodelling and tissue factor the initiator of blood coagulation at the endothelial and leukocyte surface. They constitute a secretion pathway for IL-ip and up-regulate the proinflammatory response of target cells. Microparticles circulate at low levels in healthy individuals but undergo phenotypic and quantitative changes that could play a pathophysiological role in inflammatory diseases. Microparticles may participate in the pathogenesis of sepsis through multiple ways. They are able to regulate vascular tone and are potent vascular proinflammatory and procoagulant mediators. Microparticles abilities are of increasing interest in deciphering the mechanisms underlying the multiple organ dysfunction of septic shock. Introduction In the 1960s and 70s Wolf 1 was the first to describe platelet derivatives of less than pm as procoagulant vesicles. Later having been given the name of microparticles MPs these vesicles were described as membrane-derived nano-fragments to 1 pm that Correspondence 3lnstitut d Hématologie et d lmmunologie Faculté de Médecine Université de Strasbourg 4 rue Kirschlegef .