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Báo cáo y học: " Scavenger properties of cultivated pig liver endothelial cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Scavenger properties of cultivated pig liver endothelial cells. | BioMed Central Comparative Hepatology Research Open Access Scavenger properties of cultivated pig liver endothelial cells Kjetil H Elvevold 1 Geir I Nedredal2 Arthur Revhaug2 and Bârd Smedsrod1 Address department of Experimental Pathology Institute of Medical Biology University of Tromso 9038 Tromso Norway and department of Digestive Surgery University Hospital of Tromso 9038 Tromso Norway Email Kjetil H Elvevold - kjetilhe@fagmed.uit.no Geir I Nedredal - geir.ivar.nedredal@fagmed.uit.no Arthur Revhaug - arthur.revhaug@unn.no Bârd Smedsrod - bard.smedsrod@fagmed.uit.no Corresponding author Published 12 August 2004 Received 22 April 2004 Accepted 12 August 2004 Comparative Hepatology 2004 3 4 doi 10.1186 1476-5926-3-4 This article is available from http www.comparative-hepatology.cOm content 3 1 4 2004 Elvevold et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The liver sinusoidal endothelial cells LSEC and Kupffer cells constitute the most powerful scavenger system in the body. Various waste macromolecules continuously released from tissues in large quantities as a consequence of normal catabolic processes are cleared by the LSEC. In spite of the fact that pig livers are used in a wide range of experimental settings the scavenger properties of pig LSEC has not been investigated until now. Therefore we studied the endocytosis and intracellular transport of ligands for the five categories of endocytic receptors in LSEC. Results Endocytosis of five 125I-labelled molecules collagen a-chains FITC-biotin-hyaluronan mannan formaldehyde-treated serum albumin FSA and aggregated gamma globulin AGG was substantial in cultured LSEC. The endocytosis was mediated via the collagen- hyaluronan- mannose- scavenger- .