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Báo cáo y học: " HTLV-1 p30II: selective repressor of gene expression"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: HTLV-1 p30II: selective repressor of gene expression | Retrovirology BioMed Central Commentary HTLV-1 p30H selective repressor of gene expression Patrick L Green 1 2 3 4 Open Access Address department of Veterinary Biosciences The Ohio State University Columbus OH 43210 USA 2Molecular Virology Immunology and Medical Genetics The Ohio State University Columbus OH 43210 USA 3Center for Retrovirus Research The Ohio State University Columbus OH 43210 USA and 4Comprehensive Cancer Center Arthur G. James Cancer Hospital and Solove Research Institute The Ohio State University Columbus OH 43210 UsA Email Patrick L Green - green.466@osu.edu Corresponding author Published 24 November 2004 Retrovirology 2004 1 40 doi l0.ll86 l 742-4690-1-40 Received 09 November 2004 Accepted 24 November 2004 This article is available from http www.retrovirology.com content 1 1 40 2004 Green licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Human T-lymphotropic virus type-1 HTLV-1 is a complex retrovirus that causes adult T-cell leukemia lymphoma ATL and is implicated in a variety of lymphocyte-mediated disorders. HTLV- 1 pX ORF II encodes two proteins p13H and p30H whose roles are beginning to be defined in the virus life cycle. Previous studies indicate the importance of these viral proteins in the ability of the virus to maintain viral loads and persist in an animal model of HTLV-1 infection. Intriguing new studies indicate that p30II is a multifunctional regulator that differentially modulates CREB and Tax- responsive element-mediated transcription through its interaction with CREB-binding protein CBP p300 and specifically binds and represses tax rex mRNA nuclear export. A new study characterized the role of p30H in regulation of cellular gene expression using comprehensive human gene arrays. .