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Báo cáo y học: " Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably? | Retrovirology BioMed Central Review Open Access Is HIV-1 RNA dimerization a prerequisite for packaging Yes no probably Rodney S Russell1 2 Chen Liang1 3 and Mark A Wainberg 1 2 3 Address 1McGill AIDS Centre Lady Davis Institute Jewish General Hospital 3755 Cote Ste-Catherine Road Montreal Quebec Canada H3T 1E2 2Department of Microbiology Immunology Montreal Quebec Canada H3A 2B4 and 3Department of Medicine McGill University Montreal Quebec Canada H3A 2B4 Email Rodney S Russell - rodruss@hotmail.com Chen Liang - chen.liang@mcgill.ca Mark A Wainberg - mark.wainberg@mcgill.ca Corresponding author Published 02 September 2004 Received 15 July 2004 Accepted 02 September 2004 Retrovirology 2004 1 23 doi 10.1186 1742-4690-1-23 This article is available from http www.retrovirology.cOm content 1 1 23 2004 Russell et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract During virus assembly all retroviruses specifically encapsidate two copies of full-length viral genomic RNA in the form of a non-covalently linked RNA dimer. The absolute conservation of this unique genome structure within the Retroviridae family is strong evidence that a dimerized genome is of critical importance to the viral life cycle. An obvious hypothesis is that retroviruses have evolved to preferentially package two copies of genomic RNA and that dimerization ensures the proper packaging specificity for such a genome. However this implies that dimerization must be a prerequisite for genome encapsidation a notion that has been debated for many years. In this article we review retroviral RNA dimerization and packaging highlighting the research that has attempted to dissect the intricate relationship between these two processes in the context of HIV-1 and .