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Design, synthesis, and in vitro antitumor activity of 6-aryloxyl substituted quinazoline derivatives
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Quinazoline derivatives are a class of important antitumor drugs known as small molecule inhibitors that include epidermal growth factor receptor (EGFR) inhibitors. Based on the structure of poziotinib, a series of 6-aryloxyl substituted quinazoline derivatives were designed and synthesized. The molecular docking results suggested that compound 4m has different binding modes to the wild-type and mutated EGFR. |