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Studying the relationship between plasma dopamine levels and clinical characteristics of bipolar disorder, manic episode

Objectives: To investigate the relationship between plasma dopamine level and clinical features in patients with bipolar disorder, manic episode. Subjects and methods: The study included 62 inpatients with bipolar disorder, manic episode, who were received treatment at National Psychiatric Hospital No 1, from July 2015 to December 2017. | Journal of military pharmaco-medicine n06-2018 STUDYING THE RELATIONSHIP BETWEEN PLASMA DOPAMINE LEVELS AND CLINICAL CHARACTERISTICS OF BIPOLAR DISORDER, MANIC EPISODE Nguyen Manh Phat*; Ngo Ngoc Tan**; Nguyen Trong Dao** SUMMARY Objectives: To investigate the relationship between plasma dopamine level and clinical features in patients with bipolar disorder, manic episode. Subjects and methods: The study included 62 inpatients with bipolar disorder, manic episode, who were received treatment at National Psychiatric Hospital No 1, from July 2015 to December 2017. Use criteria ICD-10 for diagnosis. Use method of prospective, cross-sectional, case-by-case analysis. Test plasma dopamine twice (first time in week 1, second time after first time 25 - 30 days). The data were processed by medical statistics using program STATA 12.0. Results: After a period of treatment, mean plasma dopamine levels in patients decreased significantly with p 0.05 F31.1 13 27.28 ± 4.44 17.30 ± 6.44 p 0.05 Explosive mood n = 21 35.30 ± 8.84 n=2 24.71 ± 2.65 p > 0.05 Tensive mood n = 30 32.75 ± 7.32 n=3 21.60 ± 5.71 p 0.05 Agitated activity n = 31 33.88 ± 7.93 n=1 22.84 ± 0.00 p 0.05 (1: t1 - t2 = 8.6597 and p = 0.001; 2: t1 - t2 = 8.9810 and p = 0.035; 3: t1 - t2 = 2.5769 and p = 0.738; 4: t1 - t2 = 11.0361 and p = 0.0181; 5: t1 - t2 = 5.6708 and p = 0.408) Plasma dopamine levels in 2 surveys of hyperactivity were statistically significant differenct with p < 0.01. Plasma dopamine levels in 2 surveys of interfering in everything and hysterical activity were statistically significant differences (p < 0.05). Table 5: Relationship between plasma dopamine levels and delusions. Plasma dopamine levels (ng/L) Statistical index Test 1 time (t1) Kind of delusion Test 2 time (t2) p1 = p2 n = 62 ( X ± SD) n = 62 ( X = SD) Delusion of persecution n = 19 37.41 ± 7.12 n=0 0 0 Grandiose delusions n = 42 33.95 ± 7.01 n=4 14.60 ± 1.10 p < 0.001 Delusion of .