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Diterpenoids from fokienia hodginsii

In continuous research on the chemical constituents of the twigs and leaves of Fokienia hodginsii (Dunn) A. Henry et Thomas growing in Highland, Lam Dong province 4 diterpenoids, including 3-oxo-totarol (totarolone, 1), 3βhydroxytotarol (2), 15-nor-labda-8(17),12E-diene-14-carboxaldehyde-19-oic acid (3) and 13-oxo-15,16-dinorlabda8(17),11E-diene-19-oic acid (4) were isolated. | Vietnam Journal of Chemistry, International Edition, 55(5): 557-560, 2017 DOI: 10.15625/2525-2321.2017-00507 Diterpenoids from Fokienia hodginsii Dang Viet Hau1,2, Nguyen Thanh Tam1,2, Tran Duc Quan1, Dao Duc Thien1, Bui Xuan Tinh3, Le Thi Hong Nhung4, Tran Van Loc1, Tran Van Sung1, Trinh Thi Thuy1,2* 1 Institute of Chemistry, Vietnam Academy of Science and Technology 2 Graduate University of Science and Technology, Vietnam Academy of Science and Technology 3 Quang Trung University 4 Hanoi University of Industry Received 27 July 2017; Accepted for publication 28 August 2017 Abstract In continuous research on the chemical constituents of the twigs and leaves of Fokienia hodginsii (Dunn) A. Henry et Thomas growing in Highland, Lam Dong province 4 diterpenoids, including 3-oxo-totarol (totarolone, 1), 3βhydroxytotarol (2), 15-nor-labda-8(17),12E-diene-14-carboxaldehyde-19-oic acid (3) and 13-oxo-15,16-dinorlabda8(17),11E-diene-19-oic acid (4) were isolated. Their structures were elucidated by the spectroscopic methods and comparison with reported data. This is the first report on the isolation of compounds 1, 2 and 3 from this plant. Keywords. Fokienia hodginsii; totarane; nor-labdane diterpenoid. 1 1. INTRODUCTION Fokienia hodginsii (Dunn) A. Henry et Thomas (synonym Cupressus hodginsii Dunn)-“local name Pơ mu”- belongs to family Cupressaceae. It is a big tree, 20-30 m tall, mainly distributed in China and Vietnam [1]. Po mu tree is known for its beauty, fragrance and high-value wood. Previous investigations of this plant have been mainly focused on the chemical composition of the essential oil [2]. Hitherto, there is only one report on the chemical constituents of this species growing in China. Its main components included diterpenoids: isopimarane, labdane, and icetexane [2]. In our previous chemical investigation, from the ethyl acetate extract of twigs and leaves of this plant growing in Highland, Lam Dong province there yielded two megastigmanes, namely