tailieunhanh - Potential mortalin-P53 complex abrogation of ent-kaurane diterpenoids from croton tonkinensis revealed by homology modeling and docking simulation

In this study, we conducted cytotoxicity assay of 7 ent-kaurane diterpenoids from Croton tonkinensis against HepG2 cancer cell line. Homology modeling was used to determine the 3D structure of mortalin and p53 crystal structure involved mortalin-binding site was selected. All studied compounds were submitted for molecular docking to investigate inhibition mechanism of bioactive compounds. |

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