tailieunhanh - Diterpenoids from the wood of Podocarpus neriifolitus

Using combined chromatographic methods, three known diterpenoids, inumakiol D (1), totarol (2) and totarol-19- carboxylic acid (3) along with β-sitosterol and β-sitosterol glucoside were isolated from the ethyl acetate extract of the wood of Podocarpus neriifolius collected in Lam Dong province, Vietnam. Their structures were determined by MS, 1D-, 2D-NMR data analysis and comparison with published references. This is the first report of compounds 1-3 from this plant. | Vietnam Journal of Chemistry, International Edition, 54(4): 488-490, 2016 DOI: Diterpenoids from the wood of Podocarpus neriifolitus Nguyen Hoang Sa1, Nguyen Thanh Tam2, Nguyen Thi Hoang Anh2, Dao Duc Thien2, Tran Duc Quan2, Dinh Thi Phong3, Le Quoc Thang4, Tran Van Sung2, Trinh Thi Thuy2* 1 Nha Trang College of Education, 01 Nguyen Chanh road, Nhatrang, Khanhhoa 2 Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 3 4 Vietnam National Museum of Nature, VAST Hue University’s College of Educations, 34 Le Loi, Hue City Received 22 July 2016; Accepted for publication 12 August 2016 Abstract Using combined chromatographic methods, three known diterpenoids, inumakiol D (1), totarol (2) and totarol-19carboxylic acid (3) along with β-sitosterol and β-sitosterol glucoside were isolated from the ethyl acetate extract of the wood of Podocarpus neriifolius collected in Lam Dong province, Vietnam. Their structures were determined by MS, 1D-, 2D-NMR data analysis and comparison with published references. This is the first report of compounds 1-3 from this plant. Keywords. Podocarpus neriifolius, diterpenoid, inumakiol D, totarol, totarol-19-carboxylic. 1. INTRODUCTION Podocarpus neriifolius D. Don - “Thông tre lá dài”- (Podocarpaceae) is tree with straight and round trunk, growing up to 20 - 25m high. It was sparsely distributed in primary forest areas in northern Vietnam as Nghean, Hatinh, Yenbai, Tuyenquang provinces . and found at an altitude of 2300 m in the Bidoup Nui Ba National Park, Lamdong province. A decoction of the leaves of this plant is used in Vietnamese traditional medicine for the treatment of rheumatism and joint pain [1]. There have been some reports on the presence of flavonoids, diterpenoids in this plant [2-4]. In our research on the chemical constituents of Pinales species, three diterpenoids, inumakiol D (1), totarol (2) and totarol-19-carboxylic acid (3) and along with β-sitosterol and .