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Assesment of antidermatophyte activity of oil from Curcuma longa L. in vitro

This study was carried out in order to evaluate inhibition activity of oil from Vietnamese turmeric against two strains dermatophyte, Trychophytol mentargrohytes and Candida albicans. The oil from Vietnamese turmeric was obtained by hydrodistillation method and its chemical composition was determined by GC/MS. | TẠP CHÍ SINH HỌC, 2013, 35(2): 206-211 ASSESMENT OF ANTIDERMATOPHYTE ACTIVITY OF OIL FROM CURCUMA LONGA L. IN VITRO Nguyen Thi Mai Huong1, Pham Viet Cuong2, Nguyen Thi Kim Cuc2* 1 2 University of Economic and Technical Industries Institute of Marine Biochemistry, VAST, *kcnguyenthi@gmail.com ABSTRACT: Curcuma longa L. is a rhizomatous herbaceous perennial plant, and its essential oil showed antifungal, antibacterial, antioxydant, antivenom, and antitumor effects. The antidermatophytes of oil from turmeric was demonstrated. This study was carried out in order to evaluate inhibition activity of oil from Vietnamese turmeric against two strains dermatophyte, Trychophytol mentargrohytes and Candida albicans. The oil from Vietnamese turmeric was obtained by hydrodistillation method and its chemical composition was determined by GC/MS. By comparing with authentic reference compounds in mass spectra library Nist 98.1 and Wiley 275.L, 13 compounds of oil from Vietnamese turmeric were identified. The received results showed that, the oil is rich in turmerones (about 44%), which has been recognized as major constituent attributing to antimicrobial activity. By disc diffusion method, the antifungal activity of the turmeric essential oil against T. mentargrophyte and C. albicans was demonstrated. The MICs of the turmeric oil for T. mentargrophytes và C. albicans were 0.5%. The minimal killing time for C. albicans was 60 minutes and for T. mentargrophyte was 90 minutes after treatment with the turmeric oil. Keywords: Curcuma longa, dermatophytes, inhibition, turmeric oil, turmerones. INTRODUCTION Dermatophytoses is the common forms of fungal infection found in most countries. The diseases are caused by dermatophytes, the molds that require keratin for nutrition and must live on stratum corneum, hair, or nails to survive. The infection can be transmitted from man to man, animal to man and even from soil to man. Trichophyton mentagrophytes is a pathogenic agent causing tinea