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Báo cáo y học: "Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep. | Available online http ccforum.eom content 1 2 6 R146 Research Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep Kristine Waerhaug1 Mikhail Y Kirov1 2 Vsevolod V Kuzkov1 2 Vladimir N Kuklin1 and Lars J Bjertnaes1 1 Department of Anesthesiology Institute of Clinical Medicine Faculty of Medicine University of Tromso 9037 Tromso Norway 2Department of Anesthesiology Northern State Medical University Troitzky avenue 51 163000 Arkhangelsk Russian Federation Corresponding author Lars J Bjertnaes lars.bjertnaes@fagmed.uit.no Received 7 Oct 2008 Revisions requested 25 Oct 2008 Revisions received 7 Nov 2008 Accepted 20 Nov 2008 Published 20 Nov 2008 Critical Care 2008 12 R146 doi 10.1186 cc7128 This article is online at http ccforum.com content 12 6 R1 46 2008 Waerhaug et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Acute lung injury ALI may arise both after sepsis and non-septic inflammatory conditions and is often associated with the release of fatty acids including oleic acid OA . Infusion of OA has been used extensively to mimic ALI. Recent research has revealed that intravenously administered recombinant human activated protein C rhAPC is able to counteract ALI. Our aim was to find out whether rhAPC dampens OA-induced ALI in sheep. Methods Twenty-two yearling sheep underwent instrumentation. After 2 days of recovery animals were randomly assigned to one of three groups a an OA rhAPC group n 8 receiving OA 0.06 mL kg infused over the course of 30 minutes in parallel with an intravenous infusion of rhAPC 24 mg kg per hour over the course of 2 hours b an OA group n 8 receiving OA as above or c a sham-operated group n 6 . After 2 hours sheep were .