tailieunhanh - Báo cáo y học: "Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model. | Available online http content 13 6 R203 Research Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model Toshiaki Iba1 Etsuro Nakarai1 Toshio Takayama1 Kenji Nakajima2 Tetsumasa Sasaoka2 and Yoichi Ohno2 Department of Emergency and Disaster Medicine Juntendo University 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421 Japan 2Pharmaceutical Research Laboratory Nihon Pharmaceutical Co. LTD. 26 Sumiyoshi-cho Izumisano Ohsaka 598-8558 Japan Corresponding author Toshiaki Iba toshiiba@ Received 27 Sep 2009 Revisions requested 5 Nov 2009 Revisions received 25 Nov 2009 Accepted 14 Dec 2009 Published 14 Dec 2009 Critical Care 2009 13 R203 doi cc8210 This article is online at http content 13 6 R203 2009 Iba et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Recombinant human soluble thrombomodulin rhsTM is newly developed for the treatment of DIC. The purpose of this study was to evaluate the efficacy of the concomitant administration of rhsTM and antithrombin AT . Methods In the first series rats were treated with either 125 250 or 500 IU kg n 6 each of AT or 25 or mg kg n 6 each of rhsTM followed by lipopolysaccharide LPS injection. 8 h later the fibrinogen level was examined. In the second series TM group was pretreated with mg kg of rhsTM AT group was pretreated with 125 IU kg of AT AT TM group was pretreated with both AT and rhsTM and control group was pretreated with saline n 7 each . The platelet count fibrinogen ALT LDH and high-mobility group box 1 HMGB1 levels were measured. In addition histologic changes in liver were examined. In the third series .