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Báo cáo y học: " Use of different but overlapping determinants in a retrovirus receptor accounts for non-reciprocal interference between xenotropic and polytropic murine leukemia viruses"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Use of different but overlapping determinants in a retrovirus receptor accounts for non-reciprocal interference between xenotropic and polytropic murine leukemia viruses | Retrovirology BioMed Central Research Open Access Use of different but overlapping determinants in a retrovirus receptor accounts for non-reciprocal interference between xenotropic and polytropic murine leukemia viruses Neal S Van Hoeven1 2 3 and A Dusty Miller 1 Address 1Division of Human Biology Fred Hutchinson Cancer Research Center Seattle Washington 98109 USA 2Molecular and Cellular Biology Program Fred Hutchinson Cancer Research Center Seattle Washington 98109 USA and 3Current address Centers for Disease Control Atlanta Georgia 30333 USA Email Neal S Van Hoeven - nvanhoeven@cdc.gov A Dusty Miller - dmiller@fhcrc.org Corresponding author Published 15 December 2005 Received 13 September 2005 Accepted 15 December 2005 Retrovirology 2005 2 76 doi 10.1186 1742-4690-2-76 H This article is available from http www.retrovirology.cOm content 2 1 76 2005 Van Hoeven and Miller licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Retrovirus infection depends on binding of the retroviral envelope Env protein to specific cell-surface protein receptors. Interference or superinfection resistance is a frequent consequence of retroviral infection and occurs when newly-synthesized Env binds to receptor proteins resulting in a block to entry by retroviruses that use the same receptors. Three groups of viruses demonstrate a non-reciprocal pattern of interference NRI which requires the existence of both a common receptor utilized by all viruses within the group and a specific receptor that is used by a subset of viruses. In the case of amphotropic and 10A1 murine leukemia viruses MLV the common and specific receptors are the products of two related genes. In the case of avian sarcoma and leukosis virus types B D and E the two