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Báo cáo hóa học: " Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study | Cepkova et al. Annals of Intensive Care 2011 1 18 http www.annalsofintensivecare.eom content 1 1 18 Ù Annals of Intensive Care a SpringerOpen Journal RESEARCH Open Access Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation an observational cohort study ft I s -J L . I - 1 2 3 4 Ỉ - I s L I I u- 1 2 3 4 y I r- E. I II 1 2 3 4 I I fs KỲ 1 I I I 1 2 3 4 I_I L . I I L . -J 7 1 . I I f 1 2 3 4 r k If- f-. r f V 1 2 3 4 Iviagda CepKova Vineet Kapur Xiusnui Ren Thomas Quinn Hanjing Zhuo Elyse rosier Michael A Matthay1 2 3 4 and Kathleen D Liu1 2 3 4 Abstract Background The primary objective of this study was to examine levels of B-type natriuretic peptide BNP in mechanically ventilated patients with acute lung injury and to test whether the level of BNP would be higher in patients with right ventricular dilatation and would predict mortality. Methods This was a prospective observational cohort study of 42 patients conducted in the intensive care unit of a tertiary care university hospital. BNP was measured and transthoracic echocardiography was performed within 48 hours of the onset of acute lung injury. The left ventricular systolic and diastolic function right ventricular systolic function and cardiac output were assessed. BNP was compared in patients with and without right ventricular dilatation as well as in survivors versus nonsurvivors. Results BNP was elevated in mechanically ventilated patients with acute lung injury median 420 pg ml 25-75 interquartile range 156-728 pg ml . There was no difference between patients with and without right ventricular dilatation 420 pg ml 119-858 pg ml vs. 387 pg ml 156-725 pg ml p 0.96 . There was no difference in BNP levels between the patients who died and those who survived at 30 days 420 pg ml 120-728 pg ml vs. 385 pg ml 159-1070 pg ml p 0.71 . Conclusions In patients with acute lung injury the level of BNP is increased but there is no .