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Báo cáo hóa học: " CdTe quantum dots with daunorubicin induce apoptosis of multidrug-resistant human hepatoma HepG2/ADM cells: in vitro and in vivo evaluation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: CdTe quantum dots with daunorubicin induce apoptosis of multidrug-resistant human hepatoma HepG2/ADM cells: in vitro and in vivo evaluation | o Nanoscale Research Letters a SpringerOpen Journal CdTe quantum dots with daunorubicin induce apoptosis of multidrug-resistant human hepatoma HepG2 ADM cells in vitro and in vivo evaluation Zhang et al. BioMed Central Zhang et al. Nanoscale Research Letters 2011 6 418 http www.nanoscalereslett.com content 6 1 418 13 June 2011 Zhang et al. Nanoscale Research Letters 2011 6 418 http www.nanoscalereslett.eom content 6 1 418 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access CdTe quantum dots with daunorubicin induce apoptosis of multidrug-resistant human hepatoma HepG2 ADM cells in vitro and in vivo evaluation Gen Zhang 1 Lixin Shi2 Matthias Selke2 and Xuemei Wang1 Abstract Cadmium telluride quantum dots Cdte QDs have received significant attention in biomedical research because of their potential in disease diagnosis and drug delivery. In this study we have investigated the interaction mechanism and synergistic effect of 3-mercaptopropionic acid-capped Cdte QDs with the anti-cancer drug daunorubicin DNR on the induction of apoptosis using drug-resistant human hepatoma HepG2 ADM cells. Electrochemical assay revealed that Cdte QDs readily facilitated the uptake of the DNR into HepG2 ADM cells. Apoptotic staining DNA fragmentation and flow cytometry analysis further demonstrated that compared with Cdte QDs or DNR treatment alone the apoptosis rate increased after the treatment of Cdte QDs together with DNR in HepG2 ADM cells. We observed that Cdte QDs treatment could reduce the effect of P-glycoprotein while the treatment of Cdte QDs together with DNR can clearly activate apoptosis-related caspases protein expression in HepG2 ADM cells. Moreover our in vivo study indicated that the treatment of Cdte QDs together with DNR effectively inhibited the human hepatoma HepG2 ADM nude mice tumor growth. The increased cell apoptosis rate was closely correlated with the enhanced inhibition of tumor growth in the studied animals. Thus Cdte QDs combined .