tailieunhanh - Báo cáo hóa học: " Interaction of Water-Soluble CdTe Quantum Dots with Bovine Serum Albumin"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Interaction of Water-Soluble CdTe Quantum Dots with Bovine Serum Albumin | Poderys et al. Nanoscale Res Lett 2011 6 9 http content 6 1 9 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Interaction of Water-Soluble CdTe Quantum Dots with Bovine Serum Albumin 2 3 Vilius Poderys 1 Marija Matulionyte Algirdas Selskis Ricardas Rotomskis 1 Abstract Semiconductor nanoparticles quantum dots are promising fluorescent markers but it is very little known about interaction of quantum dots with biological molecules. In this study interaction of CdTe quantum dots coated with thioglycolic acid TGA with bovine serum albumin was investigated. Steady state spectroscopy atomic force microscopy electron microscopy and dynamic light scattering methods were used. It was explored how bovine serum albumin affects stability and spectral properties of quantum dots in aqueous media. CdTe-TGA quantum dots in aqueous solution appeared to be not stable and precipitated. Interaction with bovine serum albumin significantly enhanced stability and photoluminescence quantum yield of quantum dots and prevented quantum dots from aggregating. Introduction Since the first time fluorescent semiconductor nanoparticles quantum dots were synthesized they are widely explored due to their possible applications in many fields including medicine. Tunable emission wavelength broad absorption and sharp emission spectra high quantum yield QY resistance to chemical degradation and photo bleaching and versatility in surface modification make quantum dots very promising fluorescent markers 1 . Quantum dots can be used for live cell labeling ex vivo detection and imaging of cancer cells ex vivo 2 as a specific marker for healthy and diseased tissues labeling 3 for labeling healthy and cancerous cells in vivo 4 and for treatment of cancer using photodynamic therapy 5 . Despite all unique photo physical properties some problems must be solved before quantum dots can be successfully applied in medicine. Quantum dots usually are water