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Báo cáo khoa học: "Kidney function assessment in the critically ill child: is it time to leave creatinine behind"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Kidney function assessment in the critically ill child: is it time to leave creatinine behind? | Available online http ccforum.eom content 11 3 141 Commentary Kidney function assessment in the critically ill child is it time to leave creatinine behind Stuart L Goldstein Texas Children s Hospital 6621 Fannin Street MC 3-2482 Houston TX 77030 USA Corresponding author Stuart L Goldstein stuartg@bcm.edu Published 15 June 2007 This article is online at http ccforum.com content 11 3 141 2007 BioMed Central Ltd Critical Care 2007 11 141 doi 10.1186 cc5935 See related research by Herrero-Morin et al. http ccforum.com content 11 3 R59 Abstract The accurate diagnosis of acute kidney injury AKI is especially problematic in critically ill patients in whom renal function is in an unsteady state rendering creatinine-based baseline assessment measures of renal function potentially inadequate. Herrero-Morin and colleagues performed a cross-sectional analysis of the ability of cystatin C and P2 microglobulin to reflect creatinine clearance in pediatric patients with AKI. The aim of this commentary is to review the current state of AKI clinical and translational research in the light of the results presented in that study. Current standard assessments of renal function for pediatric patients use serum creatinine or formulas based on serum creatinine designed for longitudinal assessment of baseline renal function. The accurate diagnosis of acute kidney injury AKI is especially problematic in critically ill patients in whom renal function is in an unsteady state thus rendering such creatinine-based baseline assessment measures of renal function potentially inadequate. Pediatric patients comprise a valuable cohort for study because they usually do not carry many of the co-morbidities that often confound adult patient studies. In this issue of Critical Care Herrero-Morin and colleagues assess the ability of two markers cystatin C and P2 microglobulin P2M to detect decreases in renal function accurately in 25 critically ill children 1 . The authors conducted a careful study to .