tailieunhanh - Báo cáo khoa học: "Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function. | Available online http content 10 4 R118 Research Effects of prolonged endotoxemia on liver skeletal muscle and kidney mitochondrial function Francesca Porta1 Jukka Takala1 Christian Weikert1 Hendrik Bracht1 Anna Kolarova1 Bernhard H Lauterburg2 Erika Borotto1 and Stephan M Jakob1 Department of Intensive Care Medicine University Hospital Bern Switzerland department of Clinical Pharmacology University Hospital Bern Switzerland Corresponding author Stephan M Jakob Received 27 Jan 2006 Revisions requested 9 Mar 2006 Revisions received 29 Jun 2006 Accepted 8 Aug 2006 Published 8 Aug 2006 Critical Care 2006 10 R118 doi cc5013 This article is online at http content 10 4 R118 2006 Porta et al. licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Sepsis may impair mitochondrial utilization of oxygen. Since hepatic dysfunction is a hallmark of sepsis we hypothesized that the liver is more susceptible to mitochondrial dysfunction than the peripheral tissues such as the skeletal muscle. We studied the effect of prolonged endotoxin infusion on liver muscle and kidney mitochondrial respiration and on hepatosplanchnic oxygen transport and microcirculation in pigs. Methods Twenty anesthetized pigs were randomized to receive either endotoxin or saline infusion for 24 hours. Muscle liver and kidney mitochondrial respiration was assessed. The cardiac output thermodilution and the carotid superior mesenteric and kidney arterial portal venous ultrasound Doppler and microcirculatory blood flow laser Doppler were measured and systemic and regional oxygen transport and lactate exchange were calculated. Results Endotoxin infusion induced hyperdynamic shock and .