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Báo cáo y học: " Lower lid entropion secondary to treatment with alpha-1a receptor antagonist: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Lower lid entropion secondary to treatment with alpha-1a receptor antagonist: a case report | Waqar and Simcock Journal of Medical Case Reports 2010 4 77 http www.jmedicalcasereports.eom content 4 1 77 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Lower lid entropion secondary to treatment with alpha-1a receptor antagonist a case report Salman Waqar Peter Simcock Abstract Introduction The use of alpha-1a receptor antagonists tamsulosin is widely accepted in the treatment of benign prostatic hypertrophy BPH . It has previously been implicated as a causative agent in intra-operative floppy iris syndrome due to its effects on the smooth muscle. We report a case of lower lid entropion that may be related to a patient commencing treatment of tamsulosin. Case presentation A 74-year-old Caucasian man was started on alpha 1-a receptor antagonist Tamsulosin treatment for benign prostatic hypertrophy. Eight days later he presented to the ophthalmology unit with a right lower lid entropion which was successfully treated surgically with a Weiss procedure. Conclusion We report a case of lower lid entropion that may be secondary to the recent use of an alpha-1a blocker tamsulosin . This can be explained by considering the effect of autonomic blockade on alpha-1 receptors in the Muller s muscle on a patient that may already have an anatomical predisposition to entropion formation due to a further reduction in muscle tone. Introduction The use of alpha-la receptor antagonists tamsulosin is widely accepted in the treatment of benign prostatic hypertrophy BPH . It has previously been implicated as a causative agent in the intra-operative floppy iris syndrome due to its effects on smooth muscle. We report a case of lower lid entropion that may be related to a patient commencing treatment with tamsulosin. Case presentation A 74-year-old Caucasian man presented to the ophthalmology outpatient clinic with a five-day history of a heavy and sore right eye. His past ocular history included cataract surgery and left penetrating keratoplasty for Fuch s endothelial .