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Báo cáo y học: "The significance of glucose, insulin and potassium for immunology and oncology: a new model of immunity"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The significance of glucose, insulin and potassium for immunology and oncology: a new model of immunity. | Journal of Immune Based Therapies and Vaccines BioMed Central Review Open Access The significance of glucose insulin and potassium for immunology and oncology a new model of immunity Albert F Hill 1 William J Polvino2 and Darcy B Wilson3 Address 1Hill Medical LLC 1755 Monaco Parkway Denver CO. 80220-1644 USA 2Rejuvenon Corporation 621 Shrewsbury Ave. Shrewsbury NJ 07702 USA and 3Torrey Pines Institute for Molecular Studies 3550 General Atomics Court San Diego CA 92121-1122. USA Email Albert F Hill - HILLSDEN1@AOL.COM William J Polvino - wpolvino@rejuvenon.com Darcy B Wilson - dbwilson@tpims.org Corresponding author Published 19 August 2005 Received 16 June 2005 Journal of Immune Based Therapies and Vaccines 2005 3 5 doi 10.1186 1476- Accepted 19 August 2005 8518-3-5 This article is available from http www.jibtherapies.Com content 3 l 5 2005 Hill et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. I. Abstract Background A recent development in critical care medicine makes it urgent that research into the effect of hormones on immunity be pursued aggressively. Studies have demonstrated a large reduction in mortality as a result of infusion with glucose insulin and potassium. Our work in the oncology setting has led us to propose that the principal reason for such an effect is that GIK stimulates lymphocytes to proliferate and attack pathogens sparing the patient the stress of infection. That suggestion is based on a new model of immunity that describes the effect of hormones on lymphocytes. We hypothesized that the application of glucose insulin thyroid and potassium would awaken inert tumor infiltrating lymphocytes to destroy the tumor. Methods The antitumor effect of a thyroxine glucose insulin and potassium TGIK .