tailieunhanh - Báo cáo y học: "Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance. | AIDS Research and Therapy BioMed Central Open Access Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy ART in sub-Saharan Africa Frequency and clinical significance Damalie Nakanjako 1 Agnes Kiragga1 Fowzia Ibrahim2 Barbara Castelnuovo1 Moses R Kamya1 and Philippa J Easterbrook1 2 Address infectious Diseases Institute Facluty of Medicine Makerere University Kampala Uganda and 2Department of HIV GUM King s College London SWZ London UK Email Damalie Nakanjako - drdamalie@ Agnes Kiragga - akiragga@ Fowzia Ibrahim - Barbara Castelnuovo - bcastelnuovo@ Moses R Kamya - mkamya@ Philippa J Easterbrook - peasterbrook@ Corresponding author Published 28 October 2008 Received 22 July 2008 AIDS Research and Therapy 2008 5 23 doi 1742-6405-5-23 Accepted 28 October 2008 This article is available from http content 5 1 23 2008 Nakanjako et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A proportion of individuals who start antiretroviral therapy ART fail to achieve adequate CD4 cell reconstitution despite sustained viral suppression. We determined the frequency and clinical significance of suboptimal CD4 reconstitution despite viral suppression SO-CD4 in an urban HIV research cohort in Kampala Uganda Methods We analyzed data from a prospective research cohort of 559 patients initiating ART between 04 04-04 05. We described the patterns of SO-CD4 both in terms of - I magnitude of CD4 cell increase a CD4 count increase 50 CD4 cells pl at 6 months 100 cells pl at 12 months and 200 cells pl at 24 months of ART and II failure to achieve a CD4 cell count above 200 .