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Báo cáo y học: "The use of moderate hypothermia during cardiac surgery is associated with repression of tumour necrosis factor-α via inhibition of activating protein-1: an experimental study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: The use of moderate hypothermia during cardiac surgery is associated with repression of tumour necrosis factor-α via inhibition of activating protein-1: an experimental study. | Available online http ccforum.eom content 10 2 R57 Research The use of moderate hypothermia during cardiac surgery is associated with repression of tumour necrosis factor-a via inhibition of activating protein-1 an experimental study Ma Qing1 Michael Woltje2 Kathrin Schumacher1 Magdalena Sokalska1 Jaime F Vazquez- Jimenez3 Ralf Minkenberg4 and Marie-Christine Seghaye1 Department of Pediatric Cardiology Aachen University Hospital Aachen Germany interdisciplinary Center for Clinical Research BIOMAT Aachen University Hospital Aachen Germany 3Department of Pediatric Cardiac Surgery Aachen University Hospital Aachen Germany 4Repges and Co. Institute for Medical Statistics Aachen Germany Corresponding author Marie-Christine Seghaye mseghaye@ukaachen.de Received 31 Oct 2005 Revisions requested 23 Jan 2006 Revisions received 12 Feb 2006 Accepted 14 Mar 2006 Published 7 Apr 2006 Critical Care 2006 10 R57 doi 10.1186 cc4886 This article is online at http ccforum.com content 10 2 R57 2006 Qing et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The use of moderate hypothermia during experimental cardiac surgery is associated with decreased expression of tumour necrosis factor TNF -a in myocardium and with myocardial protection. In order to identify the cellular mechanisms that lead to that repression we investigated the effect of hypothermia during cardiac surgery on both main signalling pathways involved in systemic inflammation namely the nuclear factor-KB NF-kB and activating protein-1 pathways. Method Twelve female pigs were randomly subjected to standardized cardiopulmonary bypass with moderate hypothermia or normothermia temperature 28 C and 37 C respectively six pigs in each group . .