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Báo cáo khoa học: "The role of high-frequency oscillatory ventilation in paediatric intensive care"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The role of high-frequency oscillatory ventilation in paediatric intensive care. | Available online http ccforum.eom content 9 3 249 Commentary The role of high-frequency oscillatory ventilation in paediatric intensive care Stephen D Playfor Consultant Paediatric Intensivist Honorary Clinical Lecturer in Paediatric Intensive Care Medicine Paediatric Intensive Care Unit Royal Manchester Children s Hospital Manchester UK Corresponding author Stephen D Playfor Stephen.playfor@cmmc.nhs.uk Published online 18 April 2005 This article is online at http ccforum.com content 9 3 249 2005 BioMed Central Ltd Critical Care 2005 9 249-250 DOI 10.1186 cc3524 See related research by Slee-Wijffels et al. in this issue http ccforum.com content 9 3 R274 Abstract Mechanical ventilation during acute respiratory failure in children is associated with development of ventilator-induced lung injury. Experimental models of mechanical ventilation that limit phasic changes in lung volumes and prevent alveolar overdistension appear to be less damaging to the lung. High-frequency oscillatory ventilation using very small tidal volumes and relatively high end-expiratory lung volumes provides a safe and effective means of delivering mechanical ventilatory support with the prospect of reducing the development of ventilator-induced lung injury. Despite theoretical advantages and convincing laboratory data however the use of high-frequency oscillatory ventilation in the paediatric population has not yet been associated with significant improvements in clinically significant outcome measures. Introduction In this issue of Critical Care Slee-Wijffels and colleagues 1 report on the use of high-frequency oscillatory ventilation HFOV as a rescue therapy for children with severe respiratory failure in the paediatric intensive care unit. They describe 51 children with severe respiratory failure initially managed with conventional mechanical ventilation who required HFOV as rescue therapy. In this retrospective study the authors looked for differences between patients with a diagnosis of .