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Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family

In Arabidopsis thaliana, the BTB⁄POZ-MATH (BPM) proteins comprise a small family of six members. They have been described previously to use their broad complex, tram track, bric-a-brac⁄POX virus and zinc finger (BTB⁄POZ) domain to assemble with CUL3a and CUL3b and potentially to serve as substrate adaptors to cullin-based E3-ligases in plants. | Arabidopsis thaliana BTB POZ-MATH proteins interact with members of the ERF AP2 transcription factor family Henriette Weber1 2 and Hanjo Hellmann1 1 Washington State University Pullman WA USA 2 Freie University Berlin Germany Keywords APETALA BPM cullin proteasome ubiquitin Correspondence H. Hellmann Washington State University Pullman WA 99164 USA Fax 1 509 335 3184 Tel 1 509 335 2762 E-mail hellmann@wsu.edu Received 17 July 2009 revised 7 September 2009 accepted 11 September 2009 doi 10.1111 j.1742-4658.2009.07373.x In Arabidopsis thaliana the BTB POZ-MATH BPM proteins comprise a small family of six members. They have been described previously to use their broad complex tram track bric-a-brac POX virus and zinc finger BTB POZ domain to assemble with CUL3a and CUL3b and potentially to serve as substrate adaptors to cullin-based E3-ligases in plants. In this article we show that BPMs can also assemble with members of the ethylene response factor Apetala2 transcription factor family and that this is mediated by their meprin and TRAF tumor necrosis factor receptor-associated factor homology MATH domain. In addition we provide a detailed description of BPM gene expression patterns in different tissues and on abiotic stress treatments as well as their subcellular localization. This work connects for the first time BPM proteins with ethylene response factor Apetala2 family members which is likely to represent a novel regulatory mechanism of transcriptional control. Structured digital abstract MINT-7262792 BPM1 uniprotkb Q8L765 physically interacts MI 0915 with RAP2-4 uni-protkb Q8H1E4 by two hybrid MI 0018 MINT-7262805 BPM1 uniprotkb Q8L765 physically interacts MI 0915 with RAP2-13 uniprotkb Q9LM15 by two hybrid MI 0018 MINT-7262749 BPM3 uniprotkb Q2V416 physically interacts MI 0915 with RAP2-4 uni-protkb Q8HẼẼ4 by two hybrid MI 0018 MINT-7262764 BPM3 uniprotkb Q2V416 physically interacts MI 0915 with RAP2-13 uniprotkb Q9LM15 by two hybrid MI 0018 MINT-7262838 .