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Báo cáo y học: " Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis. | Journal of Inflammation BioMed Central Research Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis Bailin Liang1 Zheng Song3 Bin Wu3 Debra Gardner2 David Shealy2 Xiao- Yu Song4 and Paul H Wooley 3 Address Department of Combination Products Vistakon 7500 Centurion Parkway Jacksonville FL 32256 USA 2Department of Immunobiology Centocor 145 King of Prussia Road Radnor PA 19087 USA 3Orthopaedic Research Institute 929 North St. Francis Wichita Kansas 67214 USA and 4Department of Biosurgicals Ethicon Research Development Route 22 West PO Box 151 Somerville NJ 08876 USA Email Bailin Liang - bliang1@its.jnj.com Zheng Song - zheng_song@via-christi.org Bin Wu - bin_wu@via-christi.org Debra Gardner - dgardner@its.jnj.com David Shealy - dshealy@its.jnj.com Xiao-Yu Song - xsong2@its.jnj.com Paul H Wooley - Paul_Wooley@via-christi.org Corresponding author Open Access Published 15 April 2009 Journal of Inflammation 2009 6 10 doi 10.1186 1476-9255-6-10 Received 15 October 2008 Accepted 15 April 2009 This article is available from http www.journal-inflammation.cOm content 6 1 10 2009 Liang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Interleukin-6 is a multifunctional cytokine that is critical for T B-cell differentiation and maturation immunoglobulin secretion acute-phase protein production and macrophage monocyte functions. Extensive research into the biology of IL-6 has implicated IL-6 in the pathophysiology and pathogenesis of RA. An anti-murine IL-6 mAb that neutralizes mouse IL-6 activities was tested in animal model of collagen-induced arthritis. Prophylactic treatment with anti-IL-6 mAb .