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Báo cáo y học: " Alveolar macrophages lack CCR2 expression and do not migrate to CCL2"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Alveolar macrophages lack CCR2 expression and do not migrate to CCL2. | Journal of Inflammation BioMed Central Research Open Access Alveolar macrophages lack CCR2 expression and do not migrate to CCL2 Judy M Opalek1 2 Naeem A Ali2 Jennifer M Lobb2 Melissa G Hunter2 and Clay B Marsh 2 Address department of Pathology The Ohio State University Columbus Ohio USA and department of Internal Medicine Division of Pulmonary and Critical Care Medicine The Ohio State University and Dorothy M. Davis Heart and Lung Research Institute Columbus Ohio USA Email Judy M Opalek - judy.opalek@osumc.edu Naeem AAli - naeem.ali@osumc.edu Jennifer M Lobb - jennifer.lobb@osumc.edu Melissa G Hunter - melissa.hunter@osumc.edu Clay B Marsh - clay.marsh@osumc.edu Corresponding author Published 22 September 2007 Received I February 2007 Accepted 22 September 2007 Journal of Inflammation 2007 4 19 doi 10.1186 1476-9255-4-19 This article is available from http www.journal-inflammation.cOm content 4 1 19 2007 Opalek et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The recruitment of mononuclear cells has important implications for tissue inflammation. Previous studies demonstrated enhanced CCR1 and CCR5 expression and decreased CCR2 expression during in vitro monocyte to macrophage differentiation. To date no study examined the in vivo differences in chemokine receptor expression between human peripheral blood monocytes and alveolar macrophages. Methods We examined the expression of these receptors in human peripheral blood monocytes and alveolar macrophages using microarray analysis reverse-transcriptase PCR flow cytometry and migration analyses. Results In contrast to peripheral blood monocytes alveolar macrophages did not express the CCL2 receptor CCR2 and did not migrate toward CCL2. In contrast .