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Báo cáo khoa hoc:" Searching for plasticity in dissociated cortical cultures on multi-electrode arrays"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Searching for plasticity in dissociated cortical cultures on multi-electrode arrays | Journal of Negative Results in BioMedicine BioMed Central Open Access Searching for plasticity in dissociated cortical cultures on multi-electrode arrays Daniel A Wagenaar 1 2 Jerome Pine3 and Steve M Potter 4 Address Department of Physics California Institute of Technology Caltech 103-33 Pasadena CA 91125 USA 2Present address Division of Biological Sciences Neuroscience Section University of California at San Diego 9500 Gilman Drive La Jolla CA 92093 USA 3Department of Physics California Institute of Technology Caltech 256-48 Pasadena CA 91125 USA and 4Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University 313 Ferst Drive Atlanta GA 30332-0535 USA Email Daniel AWagenaar - dwagenaar@ucsd.edu Jerome Pine - dwagenaar@ucsd.edu Steve M Potter - steve.potter@bme.gatech.edu Corresponding authors Published 26 October 2006 Received 02 June 2006 J. 1-11-1 r I Accepted 26 October 2006 Journal of Negative Results in BioMedicine 2006 5 16 doi l0.ll86 1477-5751-5-16 This article is available from http www.jnrbm.cOm content 5 1 16 2006 Wagenaar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We attempted to induce functional plasticity in dense cultures of cortical cells using stimulation through extracellular electrodes embedded in the culture dish substrate multi-electrode arrays or MEAs . We looked for plasticity expressed in changes in spontaneous burst patterns and in array-wide response patterns to electrical stimuli following several induction protocols related to those used in the literature as well as some novel ones. Experiments were performed with spontaneous culture-wide