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Báo cáo y học: " Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration. | BioMed Central Respiratory Research Research Open Access Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration Soni Pullamsetti1 Stefanie Krick1 Huseyin Yilmaz1 Hossein Ardeschir Ghofrani1 Christian Schudt2 Norbert Weissmann1 Beate Fuchs1 Werner Seeger1 Friedrich Grimminger1 and Ralph Theo Schermuly 1 Address University of Giessen Lung Center UGLC Medical Clinic II V Giessen Germany and 2Altana Pharma Constance Germany Email Soni Pullamsetti - Soni.Pullamsetti@innere.med.uni-giessen.de Stefanie Krick - Stefanie.Krick@innere.med.uni-giessen.de Huseyin Yilmaz - Huseyin.Yilmaz@innere.med.uni-giessen.de Hossein Ardeschir Ghofrani - Ardeschir.Ghofrani@innere.med.uni-giessen.de Christian Schudt - Christian.Schudt@altanapharma.com Norbert Weissmann - Norbert.Weissmann@innere.med.uni-giessen.de Beate Fuchs - Beate.Fuchs@innere.med.uni-giessen.de Werner Seeger - Werner.Seeger@innere.med.uni-giessen.de Friedrich Grimminger - Friedrich.Grimminger@innere.med.uni-giessen.de Ralph Theo Schermuly - Ralph.Schermuly@innere.med.uni-giessen.de Corresponding author Published 01 November 2005 Received 17 August 2005 Accepted 01 November 2005 Respiratory Research 2005 6 128 doi l0.ll 86 1465-9921-6-128 This article is available from http respiratory-research.com content 6 1 128 2005 Pullamsetti et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The aim of the study was to assess the chronic effects of combined phosphodiesterase 3 4 inhibitor tolafentrine administered by inhalation during monocrotaline-induced pulmonary arterial hypertension PAH in rats. Methods CD rats were given a single subcutaneous injection of monocrotaline to induce PAH. Four weeks after rats were .