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Báo cáo y học: "Endogenous laminin is required for human airway smooth muscle cell maturation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Endogenous laminin is required for human airway smooth muscle cell maturation. | BioMed Central Respiratory Research Open Access Endogenous laminin is required for human airway smooth muscle cell maturation Thai Tran1 2 3 Karol D McNeill1 2 3 William T Gerthoffer4 Helmut Unruh5 and Andrew J Halayko 1 2 3 6 Address Departments of Physiology and Internal Medicine University of Manitoba Winnipeg MB Canada 2Biology of Breathing Group Manitoba Institute of Child Health Winnipeg MB Canada 3CIHR National Training Program in Allergy and Asthma University of Manitoba Winnipeg MB Canada 4Department of Pharmacology University of Nevada School of Medicine Reno NV USA 5Section of Thoracic Surgery University of Manitoba Winnipeg MB Canada and 6Section of Respiratory Diseases University of Manitoba Winnipeg Canada Email Thai Tran - ttran@mich.ca Karol D McNeill - mcneillk@cc.umanitoba.ca William T Gerthoffer - wtg@med.unr.edu Helmut Unruh - hunruh@exchange.hsc.mb.ca Andrew J Halayko - ahalayk@cc.umanitoba.ca Corresponding author Published 12 September 2006 Received 20 June 2006 Accepted 12 September 2006 Respiratory Research 2006 7 117 doi l0.ll86 l 465-9921-7-117 This article is available from http respiratory-research.cOm content 7 1 1 17 2006 Tran et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Airway smooth muscle ASM contraction underlies acute bronchospasm in asthma. ASM cells can switch between a synthetic-proliferative phenotype and a contractile phenotype. While the effects of extracellular matrix ECM components on modulation of ASM cells to a synthetic phenotype have been reported the role of ECM components on maturation of ASM cells to a contractile phenotype in adult lung is unclear. As both changes in ECM components and accumulation of contractile ASM are features of airway wall