tailieunhanh - Báo cáo y học: "Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ. | Available online http content 7 2 R402 Research article Defective CD4 CD25 regulatory T cell functioning in collagen-induced arthritis an important factor in pathogenesis counter-regulated by endogenous IFN-y Hilde Kelchtermans1 Bert De Klerck1 Tania Mitera1 Maarten Van Balen1 Dominique Bullens2 Alfons Billiau1 Georges Leclercq3 and Patrick Matthys1 Laboratory of Immunobiology Rega Institute for Medical Research Katholieke Universiteit Leuven KULeuven Leuven Belgium laboratory for Experimental Immunology Department of Pathophysiology Faculty of Medicine Katholieke Universiteit Leuven KULeuven Leuven Belgium 3Department of Clinical Chemistry Microbiology and Immunology Ghent University Hospital Ghent Belgium Corresponding author Hilde Kelchtermans Received 8 Jul 2004 Revisions requested 25 Aug 2004 Revisions received 19 Nov 2004 Accepted 20 Dec 2004 Published 28 Jan 2005 Arthritis Res Ther 2005 7 R402-R415 DOI ar1500 2005 Kelchtermans et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Mice with a deficiency in IFN-y or IFN-y receptor IFN-yR are more susceptible to collagen-induced arthritis CIA an experimental autoimmune disease that relies on the use of complete Freund s adjuvant CFA . Here we report that the heightened susceptibility of IFN-YR knock-out KO mice is associated with a functional impairment of CD4 CD25 Treg cells. Treatment of wild-type mice with depleting anti-CD25 antibody after CFA-assisted immunisation with collagen type II CII significantly accelerated the onset of arthritis and increased the severity of CIA. This is an indication of a role of Treg cells in the effector phase of CIA. IFN-yR deficiency did not .