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Báo cáo y học: "Reduced trabecular bone mineral density and cortical thickness accompanied by increased outer bone circumference in metacarpal bone of rheumatoid arthritis patients: a cross-sectional study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Reduced trabecular bone mineral density and cortical thickness accompanied by increased outer bone circumference in metacarpal bone of rheumatoid arthritis patients: a cross-sectional study. | Aeberli et al. Arthritis Research Therapy 2010 12 R119 http arthritis-research.eom content 12 3 R119 RESEARCH ARTICLE Open Access Reduced trabecular bone mineral density and cortical thickness accompanied by increased outer bone circumference in metacarpal bone of rheumatoid arthritis patients a cross-sectional study Daniel Aeberli 1 Prisca Eser 1 Harald Bonel2 Jolanda Widmer 1 Gion Caliezi1 Pierre-Alain Varisco1 Burkhard Moller1 and Peter M Villiger1 Abstract Introduction The objective of this study was to assess three-dimensional bone geometry and density at the epiphysis and shaft of the third meta-carpal bone of rheumatoid arthritis RA patients in comparison to healthy controls with the novel method of peripheral quantitative computed tomography pQCT . Methods PQCT scans were performed in 50 female RA patients and 100 healthy female controls at the distal epiphyses and shafts of the third metacarpal bone the radius and the tibia. Reproducibility was determined by coefficient of varia-tion. Bone densitometric and geometric parameters were compared between the two groups and correlated to disease characteristics. Results Reproducibility of different pQCT parameters was between 0.7 and 2.5 . RA patients had 12 to 19 lower trabecular bone mineral density BMD P 0.001 at the distal epiphyses of radius tibia and metacarpal bone. At the shafts of these bones RA patients had 7 to 16 thinner cortices P 0.03 . Total cross-sectional area CSA at the metacarpal bone shaft of pa-tients was larger between 5 and 7 P 0.02 and relative cortical area was reduced by 13 . Erosiveness by Ratingen score correlated negatively with tra-becular and total BMD at the epiphyses and shaft cortical thickness of all measured bones P 0.04 . Conclusions Reduced trabecular BMD and thinner cortices at peripheral bones and a greater bone shaft diameter at the metacarpal bone suggest RA spe-cific bone alterations. The proposed pQCT protocol is reliable and allows measuring juxta-articular trabecular