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Báo cáo y học: "TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus. | Suh et al. Arthritis Research Therapy 2010 12 R146 http arthritis-research.eom content 12 4 R146 RESEARCH ARTICLE Open Access TAM receptor ligands in lupus Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus 1.2 1 1 3 1 Chang-Hee Suh Brendan Hilliard Sophia Li Joan T Merrill Philip L Cohen Abstract Introduction The TAM tyro 3 axl mer kinases are key regulators of innate immunity and are important in the phagocytosis of apoptotic cells. Gas6 and protein S are ligands for these TAM kinases and bind to phosphatidyl serine residues exposed during apoptosis. In animal models absence of TAM kinases is associated with lupus-like disease. To test whether human systemic lupus erythematosus SLE patients might have deficient levels of TAM ligands we measured Gas 6 and protein S levels in SLE. Methods 107 SLE patients were recruited. Of these 45 SLE patients were matched age gender and ethnicity with normal controls NC . Gas6 and free protein S were measured with sandwich enzyme linked immunosorbent assays ELISAs . Results Overall the plasma concentrations of Gas6 and free protein S were not different between 45 SLE patients and 45 NC. In SLE patients the levels of free protein S were positively correlated with age r 0.2405 P 0.0126 however those of Gas6 were not. There was no correlation between the concentrations of Gas6 and free protein S in individuals. Levels of free protein S were significantly lower in SLE patients with a history of serositis neurologic disorder hematologic disorder and immunologic disorder. Gas6 levels were elevated in patients with a history of neurologic disorder. The SLE patients with anti-Sm or anti-cardiolipin IgG showed lower free protein S levels. Circulating free protein S was positively correlated with complement component 3 C3 r 0.3858 P 0.0001 and complement component 4 C4 r 0.4275 P 0.0001 . In the patients with active BILAG hematologic involvement the levels of free protein S were lower and those of Gas6