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Báo cáo y học: "Treatment of stasis dermatitis using aminaphtone: Metronidazole-induced encephalopathy in a patient with infectious colitis: a case repo"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Treatment of stasis dermatitis using aminaphtone: Metronidazole-induced encephalopathy in a patient with infectious colitis: a case report. | Kim et al. Journal of Medical Case Reports 2011 5 63 http www.jmedicalcasereports.eom content 5 1 63 JOURNALOF medical case reports CASE REPORT Open Access Metronidazole-induced encephalopathy in a patient with infectious colitis a case report Hoon Kim1 Young Woo Kim2 Seoung Rim Kim2 Ik Seong Park2 Kwang Wook Jo2 Abstract Introduction Encephalopathy is a rare disease caused by adverse effects of antibiotic drugs such as metronidazole. The incidence of metronidazole-induced encephalopathy is unknown although several previous studies have addressed metronidazole neurotoxicity. Here we report the case of a patient with reversible cerebellar dysfunction on magnetic resonance imaging induced by prolonged administration of metronidazole for the treatment of infectious colitis. Case presentation A 71-year-old Asian man admitted to our hospital with hematochezia underwent Hartmann s operation for the treatment of colorectal cancer three years ago. He was diagnosed with an infectious colitis by colonoscopy. After taking metronidazole he showed drowsiness and slow response to verbal commands. Brain magnetic resonance imaging showed obvious bilateral symmetric hyperintensities within his dentate nucleus tectal region of the cerebellum and splenium of corpus callosum in T2-weighted images and fluid attenuated inversion recovery images. Our patient s clinical presentation and magnetic resonance images were thought to be most consistent with metronidazole toxicity. Therefore we discontinued metronidazole and his cerebellar syndrome resolved. Follow-up magnetic resonance imaging examinations showed complete resolution of previously noted signal changes. Conclusion Metronidazole may produce neurologic side effects such as cerebellar syndrome and encephalopathy in rare cases. We show that metronidazole-induced encephalopathy can be reversed after cessation of the drug. Consequently careful consideration should be given to patients presenting with complaints of neurologic disorder .